Rheum Dis Clin North Am 2006 May; 32(2): 401-12 (Read article online)

Rosenthal AK

Calcium crystals are common and under-recognized participants in osteoarthritis. Excellent evidence supports two hypotheses explaining the relationship between calcium crystal deposition and osteoarthritis. There is ample support for the theory that calcium crystals cause or worsen osteoarthritis and equally compelling evidence to support the theory that osteoarthritis causes or worsens calcium crystal formation. Further research in this area will improve understanding of the pathogenesis of these conditions and should lead to the development of effective therapy for all types of degenerative arthritis.